Journal of Medicine and Medical Science Research

Volume 1 Issue 2, Pages 24-31

©2012 Online Research Journals

Available Online at https://onlineresearchjournals.org/JMMSR

Full Length Research Article

 

Five Year Survival of Patients with Breast Cancer at the Lagos State University Teaching Hospital, Nigeria   Popoola AO*1, Ogunleye OO2,4  Ibrahim NA3, Omodele FO3, Igwilo AI1   *1Oncology Unit, Department of Radiology, Lagos State University Teaching Hospital 2Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos. 3Department of Surgery, Lagos State University Teaching Hospital, Ikeja, Lagos. 4Department of Pharmacology, Lagos State University College of Medicine, Ikeja, Lagos.   *Corresponding Author’s E-mail: pabiodun2001@yahoo.com; Tel: 234-805-204-0832, Mobile: 234-803-302-1434 Downloaded 16 March, 2012 Accepted 9 May, 2012

The objective of this study was to evaluate the overall five year survival rate, pattern of disease presentation, and to determine some factors that are predictive of five years survival among patients diagnosed and managed for breast cancer between 2005 and 2011. Background information and histological type were obtained from the patients records. Clinical, Radiological, Staging (Manchester) and site of metastasis information were obtained during pre-treatment examination and follow-up periods.  At presentation, stage III was (45.6%) followed by stage IV (35%) stage I, 2.4% and II with 16.6%. The overall five year survival in the population studied was 25.6% (45/176). Five year survival rates for patients with stages II, III and IV diseases at diagnosis were 45%, 15% and 5% respectively. Five year survival rate for early stages (I and II) was 45% while advanced stages (III&IV) was 16%. The median survival time for the patients studied was 30 (28.5-31.5 95%CI) months. Hazard ratio (HR) of 1.28(0.96-1.72) was obtained for disease stages above stage 1 at presentation relative to stage 1 disease. A greater percentage of our patient presented at young peak age of incidence in advanced stages of the disease and with aggressive tumour which may have resulted in poor survival outcome. These factors should be considered when planning health programmes to improve survival in this group of patients. Further study and researches are required to determine the characteristics of each tumour for effective treatment and better outcome.   Keywords: Breast cancer, metastasis, hazard ratio, survival outcome, stages of the disease, pattern of disease presentation, Nigeria.